Prolonged effects of anabolic steroid

Article. Prolonged effects of anabolic steroid

The purpose of this study was to inveestigate the prolonged effect of an anabolic steroid (methandrostenolone) following cessation of drug administration and a 15 week detraining period.

Medicine and Science in Sports

Published on Sunday, May 23, 2004 by Gideon Ariel

� 1974

MEDICINE AND SCIENCE IN SPORTS

Vol. 6, No. pp. 62-64,1974

Prolonged effects of anabolic steroid

upon muscular contractile force

ABSTRACT. There is an established body of literature with respect to the pharmacological properties of anabolic steroids. However, researchers have ignored the possibil

ity of latent behavior of these drugs. The purpose of this study was to inveestigate the prolonged effect of an anabolic steroid (methandrostenolone) following cessation of drug administration and a 15 week detraining period.

The population consisted of male weightlifters. A sample of twenty subjects ranging in age from 19 to 25 was used. Maximum dynamic muscular forces were determined by testing 1-RM (Repetition Maximum) in the

bench and military presses and the squat exercises. The anabolic steroid, 15 mg of methandrostenolone each day, was administered during consecutive four weeks of train

ing period which was then followed by a 15-week detraining period.

The results of the present study revealed that the increase of muscular force obtained during drug administration was significantly maintained following 15 weeks of

a detraining period. Subjects who trained without the drug lost a significant amount of their muscular forces following the detraining period.

Clinically, anabolic steroids have been used to relieve pathological cobditions involving excessive nitrogen loss and reduced protein synthesis (7,9). Interest has been further increased through the use of these steroids at the opposite end of the spectrum, i.e., in an effort to increase body mass to etfhance physical performance. World-class power event athletes are reported to be using anabolic steroids as complements to training regimens. Early work in this area has been hampered by the lack of research concerning the residual effect of anabolic steroids. Two recent studies (1,2) reveal the possibility of biochemical as well as psychological effects of anabolic steroids. Using a double-blind control, statistically significant increases in muscular force under the placebo condition, and significant changes in reflex components as a result of drug administration were observed.

The present studs’ was designed to investigate the prolonged residual effects of an anabolic steroid (15 mg of methandrostenolone daily during four consecutive weeks) following cessation of drug administration and a 15 week detraining period.

METHOD

The population consisted of male weightlifters registered at the University of ‘Massachusetts during the

Submitted for publication Marcb, 1973.

GIDEON ARIEL

University of Massachusetts Department of Exercise Science Amherst, Massachusetts

1971-1972 school year. Twenty volunteers ranging in age from 19 to 25 served as subjects in this study. Their height averaged 179.5 cm and their mean weight vas 87.25 kg.

The twenty subjects were divided into two groups. Ten subjects in group 1 (experimental group) received 15 mg of methandrostenolone, an oral anabolic steroid, daily during four consecutive weeks, while the ten subjects in group 2 (control group) received no supplement.

For a period of four weeks prior to the beginning of the drug administration, all subjects lifted weights five days a week. They were tested on the seventh day for maximum lifts in the bench and military presses and the squat exercises. Maximum dynamic contractile force measurements were determined by 1-RAM Techniques used in performing the three lifts were those prescribed by the Amateur Athletic Union rules for weightlifting competition. The anabolic steroid was administered during a subsequent four week training period which was then followed by a 15-week detraining period. During the training period the subjects exercised five times per week for approximately two hours each day according to a program designed to work the major muscle groups of the body utilizing a progressive over-load principle. The detraining period extended from June through August during which no training was reported by any of the subjects. This period constitutes the traditional summer vacation schedule, and since the subjects were absent from the campus, no formed regulatory procedures governing their activity were possible.

Analysis of variance was used in order to analyze the differences of strength levels between the training period and the detraining period for each group.

RESULTS

Figure 1 presents the strength level differences during the training period and following the detraining period. Table 1 presents the analysis of variance for the data and Table 2 presents the muscular force levels for the experimental and the control groups.

In the bench-press exercise, the experimental group lost 6.6 kg of mean force while the control group lost a mean force of 19.9 kg. In the military press, the experimental group lost a mean force of 4.76 kg compared with 9.52 kg for the control group. In the squat exercise,

PROLONGED EFFECTS OF ANABOLIC STEROIDS

63

0 AFTER TRAINING PERIOD AFTER NO TRAINING PERIOD

Y Z

W U

O LL

E E C C E E C C

BENCH PRESS MILITARY PRESS

STRENGTH LEVEL DIFFERENCES

Figure 1. Strength level differences during the training period and following the detraining period. i

E

E C SQUAT

the experimental group lost 8.44 kg compared with 15.19 kg for the control group.

Table 1 shows statistically significant differences in muscular strength level between the two experimental periods at the .01 level of confidence only for the control group.

DISCUSSION

The present study shows that the increase of muscular force obtained during drug administration was maintained following a 15 week detraining period. Subjects who trained without the drug lost a significant amount of their muscular force following the detraining period. These findings may be considered in the light of work of other investigators who found that administration of androgens and anabolic steroids results in the increased formation of extragcnital protein-containing tissue (3,4,6). Part of this extragenital protein is formed in the skeletal muscle (6), and may be maintained dur

ing the detraining period. An increase of muscular tissue due to the administration of anabolic steroids was found by several investigators (6,8 ). Korner (8) found that the chemical composition of the protein newly formed by the influence of anabolic steroids was different from that of natural protein. Johnson and O’Shea (5) emphasized the need for a “severe” exercise regimen and a protein dietary supplement to accompany the administration of the drug. The genesis of increased muscular protein, which has been observed with all anabolic steroids (6), is still unclear.

CONCLUSION

It was observed in the present study that subjects who trained with the anabolic steroid were able to maintain their strength level after the detraining period, while the subjects who trained without the anabolic steroid demonstrated a significant loss of strength. hence, it is concluded that the anabolic steroid could be actively involved in the maintenance of strength.

64 MEDICINE AND SCIENCE IN SPORTS

TABLE 1. Analysis of variance of mean strength levels between the two experimental periods.

Source of Sum of Mean

Variation Squares d.f Squares F-ratio

Experimental Group Bench-press

Grand Mean 2349551.25 1

Treatments 1051.25 1 1051.25

Error 10322.50 18 573.47 1.83 (1,18)

Control Group 1

Grand Mean 1693620.00

Treatments 9680.00 1 9680.00

Error 7950.00 18 441.67 21.92**(1,18)

Experimental Group Military-press

Grand Mean 794011.25 1

Treatments 551.25 1 551.25

Error 10162.50 18 564.58 0.98 (1,18)

Control Group 1

Grand Mean 733045.00

Treatments’ 2205.00 1 2205.00

Error 2000.00 18 111.11 19.85**(1,18)

Experimental Group Squat

Grand Mean 2675461.25 1

Treatments 1901.25 1 1901.25

Error 16912.50 18 939.58 2.02 (1,18)

Control Group 1

Grand Mean 2038411.25

Treatments 5611.25 1 5611.25

Error 4302.50 18 239.03 23.48**(1,18)

** F-ratio significant to the .01 level of confidence.

TABLE 2. Mean muscular force levels (Kg).

Exercise Experimental group Control group

Before Afters Diff Before After Diff

Bench-press 158.73 152.15 6.58 141.95 121.99 19.95**

Military-press 92.74 87.98 4.76 91.61 82.09 9.52**

Squat 170.29 161.45 8.84 152.38 137.18 15.19**

** F-ratio significant to the .01 level of confidence. REFERENCES

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